10.23645/epacomptox.6062785.v5 EPA's National Center for Computational Toxicology EPA's National Center for Computational Toxicology ToxCast Data Pipeline Overview The United States Environmental Protection Agency’s Center for Computational Toxicology and Exposure 2019 CompTox ToxCast High-Throughput Screening Toxicology 2019-03-27 14:29:13 Dataset https://epa.figshare.com/articles/dataset/CRAN_ToxCast_Data_Pipeline_R_Package/6062785 The tcpl package was developed to process high-throughput and high-content screening data generated by the ToxCast program. ToxCast is screening thousands of chemicals with hundreds of assays coming from numerous and diverse biochemical and cell-based technology platforms. The diverse data, received in heterogeneous formats from numerous vendors, are transformed to a standard computable format and loaded into the tcpl database by vendor-specific R scripts. Once data is loaded into the database, ToxCast utilizes the generalized processing functions provided in this package to process, normalize, model, qualify, flag, inspect, and visualize the data. While developed primarily for ToxCast, we have attempted to make the tcpl package generally applicable to chemical-screening community.